Document Details
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Document Type |
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Article In Journal |
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Document Title |
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pSumo-CD: predicting sumoylation sites in proteins with covariance discriminant algorithm by incorporating sequence-coupled effects into general PseAAC pSumo-CD: predicting sumoylation sites in proteins with covariance discriminant algorithm by incorporating sequence-coupled effects into general PseAAC |
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Document Language |
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English |
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Abstract |
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Motivation: Sumoylation is a posttranslational modification (PTM)
process, in which small ubiquitin-related modifier (SUMO) is attaching
by covalent bonds to substrate protein. It is critical to
many different biological processes such as replicating genome,
expressing gene, localizing and stabilizing proteins; unfortunately,
it is also involved with many major disorders including Alzheimer’s
and Parkinson’s diseases. Therefore, for both basic research and
drug development, it is important to identify the sumoylation sites
in proteins.
Results: To address such a problem, we developed a predictor
called pSumo-CD by incorporating the sequence-coupled information
into the general pseudo amino acid composition (PseAAC)
and introducing the covariance discriminant (CD) algorithm, in
which a bias-adjustment term, which has the function to automatically
adjust the errors caused by the bias due to the imbalance of
training data, had been incorporated. Rigorous cross-validations
indicated that the new predictor remarkably outperformed the
existing state-of-the-art prediction method for the same purpose.
Availability: For the convenience of most experimental scientists,
a user-friendly web-server for pSumo-CD has been established at
http://www.jci-bioinfo.cn/pSumo-CD, by which users can easily
obtain their desired results without the need to go through the
complicated mathematical equations involved. |
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ISSN |
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1460-2059 |
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Journal Name |
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Bioinformatics |
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Volume |
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32 |
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Issue Number |
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20 |
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Publishing Year |
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1437 AH
2016 AD |
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Article Type |
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Article |
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Added Date |
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Wednesday, July 12, 2017 |
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Researchers
| Jianhua Jia | Jia, Jianhua | Researcher | Doctorate | |
| Liuxia Zhang | Zhang, Liuxia | Researcher | Doctorate | |
| Zi Liu | Liu, Zi | Researcher | Doctorate | |
| Xuan Xiao | Xiao, Xuan | Researcher | Doctorate | |
| Kuo-Chen Chou | Chou, Kuo-Chen | Researcher | Doctorate | |
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